the present invention relates to a method of treatment or prevention of cardiovascular events in a subject suffering from atherosclerotic vascular disease, said method comprising the step of: (b) the administration of a therapeutically effective amount of a material of formula (i), a known derivative of colchicine and / or a salt thereof: where r1, r2, r3, r4, r3, r10.r11 and r12 represents independently a hydrogen atom, an alkyl group, c1-4 alkenyl group, a c2 - 4, a cycloalkyl group 3 - 6, a halogen atom, a group haloalkyle, c1-4, a nitro group, an amino group, an acyl amino group at c - 4. dialkylamino alkyl group or (e) n (4), a hydroxyl group, an alkoxy group, a c1-4 alkylthio group, c1 - 4a group of formula - (rx) and so2n so2rx wherein rx is a c1-4 alkyl group, an acyloxy group, c1-4, optionally substituted phenyl group or an optionally substituted phenoxy group； and r7 and 8 are independently a hydrogen atom, an alkyl group of c1 - 4 the acyl group or a c1-4； and r4, r5, r6 and r6 are independently a hydrogen atom.a c1-4 alkyl group, an alkenyl group, a group with c 4, c3) cycloalkyl, halogen atom, a group haloalkyle, c1-4, a nitro group, an amino group, an acyl amino group at c - 4, a hydroxyl group, an alkoxy group, c1 - 4 or a c1-4 alkylthio group, a group of formula - so2n (rx) 2 or so2rx wherein rx is a c1-4 alkyl group, an acyloxy group, c1-4.or a phenyl group optionally substituted.La présente invention concerne un procédé de traitement ou de prévention d'un événement cardiovasculaire chez un sujet atteint d'une maladie vasculaire athérosclérotique, ledit procédé comprenant l'étape suivante : b) administration d'une quantité thérapeutiquement efficace d'un composé de formule (i), d'un dérivé connu de colchicine et/ou d'un sel de celui-ci où : r1, r2, r3, r4, r9, r10, r11 et r12 représentent indépendamment un atome d'hydrogène, un groupe alkyle en c1-4, un groupe alcényle en c2-4, un groupe cycloalkyle en c3-6, un atome d'halogène, un groupe haloalkyl
