ANIMAUX NON HUMAINS COMPRENANT UN LOCUS TRKB HUMANISE

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专利权人:

REGENERON PHARMACEUTICALS; INC.

发明人:

MUJICA, ALEXANDER O.,TANG, YAJUN,LEE, JEFFREY D.,GAO, MIN,CROLL, SUSAN,MACDONALD, LYNN,HU, YING,ROMANO, CARMELO

申请号：

CA3076377

公开号：

CA3076377A1

申请日:

2018.11.30

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized TRKB locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized TRKB locus express a human TRKB protein or a chimeric transthyretin protein, fragments of which are from human TRKB. Methods are provided for using such non-human animals comprising a humanized TRKB locus to assess in vivo efficacy of human-TRKB-targeting reagents such as nuclease agents designed to target human TRKB.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/