AIGUADE BOSCH JOSE,GUAL ROIG SILVIA,PRAT QUINONES MARIA,PUIG DURAN CARLOS
申请号：
NZ62478412
公开号：
NZ624784A
申请日:
2012.11.09
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed are cyclohexylamine compounds of formula (A) having &bgr2 adrenergic agonist and M3 muscarinic antagonist dual activity, wherein the substituents are as defined in the specification. Also disclosed is the use of compounds of formula (A) as bronchodilator agents for the treatment of respiratory disorders such as COPD and asthma. An example of a compound of formula (A) is: Trans-4-[{ 3-[6-({ [(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino} methyl)-2-oxo-1,3-benzoxazol-3(2H)-yl]propyl} (methyl)amino]-cyclohexyl hydroxy(di-2-thienyl)acetate dihydrofluoride
