The invention concerns vaccines and the use of the naked DNA and/or RNA molecule encoding hemagglutinin (HA) from pandemic influenza, e.g. the 1918 H1N1 and/or the 1957 H2N2 and/or the 1968 H3N2 influenza A virus and/or the high pathogenic bird pandemic ATV strain (A/buzzard/Denmark/6370/06(H5N1)) and/or 2001 H5N7 low pathogenic Avian influenza virus (ATV) strain (A/Mallard/Denmark/64650/03(H5N7)) or the March 2006 Denmark H5N1 high pathogenic AIV strain (A/buzzard/Denmark/6370/06(H5N1)) or the 2008 (A/duck/Denmark/53- 147-8/08 (H7N1)) or the 2004(A/widegeon/Denmark/66174/G18/04 (H2N3)) as a vaccine component against present day and coming H1, H2, H3, H5, H7, N1, N2, N3 containing influenza A infections in humans and/or swine optionally with the naked DNA and/or RNA molecule encoding neuraminidase (NA) and/or matrix protein (M) and/or the nucleoprotein (NP) from pandemic influenza virus included. If the vaccine components are used as DNA or RNA vaccines with or without the corresponding protein, the codons can optionally be "humanized" using preferred codons from highly expressed mammalian genes and the administration of this DNA vaccine can be by saline or buffered saline injection of naked DNA or RNA, or injection of DNA plasmid or linear gene expressing DNA fragments coupled to particles. Addition of the matrix protein (M) and/or the nucleoprotein (NP) as protein or DNA from the 1918 influenza strain is also disclosed.
