David J. Yang;Dongfang Yu;F. David Rollo;Andrew S. Thompson
发明人:
David J. Yang,Dongfang Yu,Andrew S. Thompson,F. David Rollo
申请号：
US13562879
公开号：
US20130039853A1
申请日:
2012.07.31
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.
