A compound of the general Formula (I): wherein: X is -O-, -S-or -SO2-； Y is hydrogen, OH or O (C1-C4) alkyl； Z is>； = O or>； = S； R is (C3-C10) alkyl； ω-trifluoro (C3-C10) alkyl； R1 and R2 are independently hydrogen, hydroxy, (C1-C8) alkoxy, (C1-C8) alkylthio, halo, trifluoromethyl or 2,2,2-trifluoroethyl； or one of R1 and R2 is in an ortho position relative to R-X-y, together with the same R-X-, represents a group where R0 is (C2-C9) alkyl； R3 and R'3 are independently hydrogen or (C1-C4) alkyl； R4 and R5 are, independently, hydrogen, (C1-C4) alkyl； or R4 is hydrogen and R5 is a group selected from -CH2-OH, -CH2-O- (C1-C6) alkyl, -CH (CH3) -OH, - (CH2) 2-S-CH3, benzyl and 4- hydroxybenzyl； or R4 and R5, together with the adjacent carbon atom, form a (C3-C6) cycloalkyl residue； R6 and R7 are independently hydrogen or (C1-C6) alkyl； or together with the adjacent nitrogen atom they form a 5-6 membered monocyclic saturated heterocycle, optionally containing an additional heteroatom chosen from -O-, -S- and -NR8-where R8 is hydrogen or (C1-C6) alkyl； with the proviso that when X is -S-or -SO2-, then Y is not OH or O (C1-C4) alkyl； if this is the case, either as a single optical isomer in the isolated form or mixture thereof in any proportion and its pharmaceutically acceptable salts.Un compuesto de la Fórmula general (I): en donde: X es -O-, -S-o -SO2-； Y es hidrógeno, OH u O(C1-C4)alquilo； Z es >；=O o >；=S； R es (C3-C10)alquilo； ω-trifluoro(C3-C10)alquilo； R1 y R2 son, independientemente, hidrógeno, hidroxi, (C1-C8)alcoxi, (C1-C8) alquiltio, halo, trifluorometilo o 2,2,2- trifluoroetilo； o uno de R1 y R2 está en posición orto respecto a R-X-y, en conjunto con el mismo R-X-, representa un grupo donde R0 es (C2-C9)alquilo； R3 y R'3 son, independientemente, hidrógeno o (C1-C4)alquilo； R4 y R5 son, independientemente, hidrógeno, (C1-C4)alquilo； o R4 es hidrógeno y R5 es un grupo seleccionado de -CH2-OH, -CH2-O-(C1-C6)alquilo, -CH(CH3)-OH, -(CH2)2-S-CH3, bencilo y 4
