Described in the present Compounds, Methods of preparing such Compounds, Pharmaceutical compositions containing such compounds and Drugs and Methods of using such compounds to Treat or prevent diseases or conditions that require the inhibition of the biosynthesis of Heparan sulfate.Claim 1: a compound of the formula (1) where r\u00b9 is heterocicloalquilo optionally replaced with 1, 2, 3 or 4 alkyl R\u00b2 is a bicyclic Ring 9 members including 1, 2, 3 or 4 nitrogen Atoms with one or two Aromatic Rings.Where a carbon Atom in R\u00b2 is the point of Union with the pirimidinilo in formula (1) and where R\u00b2 is optionally substituted with one oxo and optionally replaced with 1, 2 or 3 r\u00b2\u1d43 groups each r\u00b2\u1d43 selected, independently, cyano, Nitro, Halo, Hydroxy, alkyd ILO, alquenilo, carboxy, alcoxicarbonilo, alquilcarbonilo, alquilsulfinilo, alquilsulfonilo,Alquilsulfoniloxialquilo, alkoxyalkyl esters, alcoxialquenilo, aminoalquilo, alquilaminoalquilo, dialquilaminoalquilo, hidroxialquilo, cycloalkyl, cicloalquilalquilo, heterocicloalquilo, heterocicloalquilalquilo, 1.3 - cyclohexanecarboxylic isoindolinilalquilo nr\u00b2\u1d47r\u00b2\u1d9c -, - and - or\u00b2\u1d48 where each heterocicloalquilo, Either alone or as part of another group, is optionally substituted with 1, 2, 3 or 4 groups selected,Independently, alkyl, Hydroxy, and alquilcarbonilo alcoxicarbonilo r\u00b2\u1d47 is Hydrogen or alkyl r\u00b2\u1d9c is Hydrogen, alkyl, aminoalquilo, alquilaminoalquilo, dialquilaminoalquilo, alkoxyalkyl esters, hidroxialquilo, alquilcarbonilo, cicloalquilcarbonilo, alquilsulfonilo,Alcoxicarbonilo cicloalquilalquilo or heterocicloalquilalquilo where the heterocicloalquilo in heterocicloalquilalquilo is optionally substituted with one or two selected groups, independently, alkyl, Hydroxy, and alquilcarbonilo alcoxicarbonilo r\u00b2\u1d48 is alkyl, haloalquilo, Hydro Xialquilo, alkoxyalkyl esters, aminoalquilo, alquilaminoalquilo, dialquilaminoalquilo, cycloal
