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Modified release formulations containing drug-ion exchange resin complexes
专利权人:
Yu-Hsing Tu;Ketan Mehta
发明人:
Ketan Mehta,Yu-Hsing Tu
申请号:
US13244748
公开号:
US08202537B2
申请日:
2011.09.26
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A solid dose composition containing a mixture of a cured, modified release-barrier coated methylphenidate-ion exchange resin complex-matrix and an uncoated methylphenidate-ion exchange resin complex is described. The barrier coated methylphenidate-ion exchange resin complex-matrix comprises methylphenidate complexed with a pharmaceutically acceptable ion-exchange resin to form the complex which is admixed with a polymer to form a methylphenidate-ion exchange resin complex-matrix, which is subsequently coated with a modified release coating. The modified coating contains polyvinyl acetate polymer and a plasticizer and is cured.
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