Sharon Gerecht,Xin Yi Chan,Quinton Smith,Yu-I Shen
申请号：
US15746477
公开号：
US20180216063A1
申请日:
2016.07.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Early vascular cells (EVCs), including endothelial cells and pericytes, are generated from hiPSCs. Unlike the isolated endothelial progenitor cells, the differentiated ECs mature and are functional. When encapsulated in synthetic hydrogel, EVCs respond to matrix cues and self-assembled to form three-dimensional EVCs. Moreover, these EVCs respond to hypoxic microenvironment and undergo vasculogenesis to form complex 3D networks.
