A pharmaceutical composition suitable for reducing frequency of urination, comprising: one or more analgesic agents selected from the group consisting of aspirin, ibuprofen, naproxen, naproxen sodium, indomethacin, nabumetone, and acetaminophen； one or more &alpha；-blockers or 5&alpha；-reductase inhibitors, and a pharmaceutically acceptable carrier wherein said one or more analgesic agents are formulated for extended release and wherein said one or more &alpha；-blockers are formulated for immediate release. The &alpha；-blocker may be tamsulosin and the 5&alpha；-reductase inhibitor may be finasteride.
