The present invention provides a novel medicine useful as a therapeutic or prophylactic agent for bile duct disease, having excellent therapeutic effect for bile duct disease. Specifically, the present invention provides a therapeutic or prophylactic agent for bile duct disease which comprises a compound represented by the compound 1, or addition salt of pharmacologically acceptable acid thereof, as effective ingredient, having specific morphinan framework.本發明為以提供具有優異膽管疾病治療效果，而對膽管疾病之治療或預防有用之新穎藥劑為目的。具體而言，本發明為提供以化合物1所代表之具有特定之嗎啡喃(morphinan)骨架之化合物或其藥理容許酸加成鹽為有效成分之膽管疾病之治療或預防劑。
