University of Twente; Institute of Biomedical Technology and Technical Medicine (MIRA)
发明人:
Liliana Sofia Moreira Teixeira,Pieter Jelle Dijkstra,Hermanus Bernardus Johannes Karperien
申请号：
US14357589
公开号：
US20140341874A1
申请日:
2012.11.14
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to a dextran-based tissuelette comprising platelet-rich plasma lysate (PRPL), which can be used for tissue repair. In particular, the tissuelette of the present invention can be adapted to display properties similar to natural cartilage, while having increased chondrocyte-attraction. Also, it has a tunable biostability that allows for degradation of the tissuelette material during natural tissue regeneration. In addition, the tissuelette displays full and covalent integration with the surrounding tissue when prepared directly at the site requiring tissue repair. The tissuelette of the present invention is primarily meant for use in cartilage repair, in particular cartilage repair upon degradation by osteoarthritis.
