Septic shock is known to lead to, at the end stage, systematic inflammatoryreaction syndrome and multiple organ failure (MOF) and cause the patients'death. Inboth diseases, the patient dies finally of MOF, and the infiltration byinflammatory cellsplays a key role for MOF. Thus, development of therapeutic agents for septicshockby suppressing the infiltration by inflammatory cells has been desired.To provide a therapeutic or preventive agent for shock, comprising as anactiveingredient a diaminotrifluoromethylpyridine derivative represented by theformula (I) orits salt:(see formula I)wherein X is a cycloalkylcarbonyl group, an alkenylcarbonyl group, athiophenecarbonyl group or a benzoyl group which may be substituted by ahalogenatom； and Y is an alkylsulfonyl group.
