The present invention relates generally to the inhibition of inflammatory cell-mediated angiogenesis. In particular, the invention concems the prevention or treatment of tumor angiogenesis, and the inhibition of tumor development, using Bv8 antagonists, such as anti-Bv8 antibodies.本發明大體係關於對發炎性細胞介導之血管生成之抑制作用。特定言之,本發明係關於使用Bv8拮抗劑(諸如,抗Bv8抗體)預防或治療腫瘤血管生成及抑制腫瘤發展。