Methods and compositions for treating cancer in patients with IDH2 mutations in combination with inhibitors of mutant IDH2 enzymes and DNA demethylating agents are provided. [Selection] Figure 1変異型IDH2酵素の阻害剤とDNA脱メチル化剤とを併用してIDH2変異を有する患者の癌を治療するための方法及び組成物を提供する。【選択図】図1