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Piperidine and pyrrolidine derivatives having NPY Y5 receptor antagonism
专利权人:
Hiroshi Yari;Kenji Takaya;Masahiro Sakagami;Hitomi Araki;Hiroshi Hashizume
发明人:
Masahiro Sakagami,Hitomi Araki,Hiroshi Hashizume,Hiroshi Yari,Kenji Takaya
申请号:
US13254750
公开号:
US08889674B2
申请日:
2010.03.05
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention discloses novel piperidine and pyrrolidine derivatives having NPY Y5 receptor antagonistic activity. Specifically, the present invention discloses a compound represented by the formula (I), a pharmaceutically acceptable salt or a solvate thereof:whereinA is substituted or unsubstituted monocyclic aryl or monocyclic heterocyclyl; X is a single bond or C(═O); Y is a single bond, CR5R6NR7 or C(═O)NR7; R1 and R2 are independently hydrogen or substituted or unsubstituted alkyl; R3 is substituted or unsubstituted aryl or heterocyclyl; R4 is halogen, substituted or unsubstituted alkyl, alkoxy, aryloxy or heterocyclyloxy, etc.; p is an integer of 0 to 2; q is 0 or 1; m is 0 or 1; n is an integer of 0 to 5; and B is aromatic carbocycle, monocyclic heterocycle or bicyclic fused hetero ring.
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