您的位置: 首页 > 农业专利 > 详情页

PREPARATION OF STABLE FORMULATIONS OF LIPID-NUCLEIC ACID COMPLEXES FOR EFFICIENT IN VIVO DELIVERY
专利权人:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
PAPAHADJOPOULOS, DEMETRIOS,HONG, DEELUNG,ZHENG, WEIWEN
申请号:
HK00102585.7
公开号:
HK1024864B
申请日:
2000.04.28
申请国别(地区):
HK
年份:
2013
代理人:
摘要:
The present invention provides for lipid:nucleic acid complexes that have increased shelf life and high transfection activity in vivo following intravenous injection, and methods of preparing such complexes. The methods generally involve contacting a nucleic acid with an organic polycation to produce a condensed nucleic acid, and then combining the condensed nucleic acid with a lipid comprising an amphiphilic cationic lipid to produce the lipid:nucleic acid complex. This complex can be further stabilized by the addition of a hydrophilic polymer attached to hydrophobic side chains. The complex can also be made specific for specific cells, by incorporating a targeting moiety such as an Fab fragment attached to a hydrophilic polymer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充