The present invention discloses a compound separated fromMonascus-fermented rice, the preparation method and uses thereof.Specifically, the present invention discloses a compound represented by theFormula I, or a pharmaceutically acceptable salt thereof, wherein, R1 isselectedfrom the group consisting of hydrogen, hydroxyl, C1-6 straight or branchedalkoxyl, (II), (III) and (IV); R2 is hydrogen or C1-6 alkyl; R3 is selectedfrom thegroup consisting of hydrogen, hydroxyl and C1-6 straight or branched alkoxyl.The present invention further discloses a pharmaceutical compositioncontaining the compound. The compound of the present invention has HMG-CoAreductase inhibition effects.(see formula I)(see formula II)(see formula III)(see formula IV)