PROBLEM TO BE SOLVED: To provide: a biocompatible composite material which is improved in the adhesion to surrounding tissue and whose strength and durability are enhanced and a method for its use in repairing tissue defects, including defects in cartilage.SOLUTION: A biocompatible composite material comprises: a woven fibrous material a hydrogel at least partially encasing the woven fibrous material, the hydrogel being formed in situ at a site of a periosteum defect, at least a portion of the hydrogel covalently bonded to periosteum and a morphogenic protein associated with the woven fibrous material. In embodiments, the repair site at which the biocompatible composite material is to be applied may be treated with a priming agent, permitting polymerization of the polymerizable agent to the tissue located at the repair site. The hydrogel comprises: a compound such as polyalkylene oxides, cellulose and polysaccharides a compound having a radically polymerizable group such as (meth)acrylate and di(meth)acrylate a crosslinking agent such as poly(L-lysine), polyethylenimine, chitosan, and glutaraldehyde and the like.COPYRIGHT: (C)2015,JPO&INPIT【課題】周囲組織との接着力が改善され、強度及び耐久性の向上した生体適合性複合材、及び、軟骨中の欠損を含む組織欠損の修復におけるその使用方法の提供。【解決手段】繊維性織布と、前記繊維性織布を少なくとも部分的に包み込むヒドロゲルで、骨膜欠損の部位にてin situで形成され、その少なくとも一部分は骨膜に共有結合されるヒドロゲルと、前記繊維性織布に関連する形態形成タンパク質と、を含む、生体適合性複合材。実施形態では、生体適合性複合材が適用される修復部位は、プライミング剤で処理して、修復部位に位置する組織への重合性剤の重合を可能とする。前記ヒドロゲルがポリアルキレンオキシド、セルロース、多糖類等の化合物、並びに(メタ)アクリレート、ジ(メタ)アクレリート等のラジカル重合性基を持つ化合物並びにポリ(L-リジン)、ポリエチレンイミン、キトサン、グルタルアルデヒド等の架橋剤等からなる、生体適合性複合剤。【選択図】図1
