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Vitamin D receptor modulators with partial agonist activity
专利权人:
Takeru Kudo;Antonio Mourino;Hiroaki Tokiwa;Sachiko Yamada;Kazuki Maekawa;Yusuke Watarai;Makoto Makishima
发明人:
Makoto Makishima,Sachiko Yamada,Antonio Mourino,Hiroaki Tokiwa,Takeru Kudo,Yusuke Watarai,Kazuki Maekawa
申请号:
US14002502
公开号:
US09018194B2
申请日:
2012.03.01
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention provides a compound which functions as a selective vitamin D receptor modulator and has action-selectivity or tissue-selectivity such that it does not induce hypercalcemia but causes other effects. There is provided a compound represented by formula (I), a solvate thereof or a prodrug thereof.wherein m and n each independently represent 1 or 0;R represents a hydrogen atom or an alkyl group;Y represents an ethane-1,1-diyl group or an ethyne-1,2-diyl group; andZ1 represents a hydrogen atom and Z2 represents a hydroxyalkoxy group, orZ1 and Z2 jointly form a methylene group.
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