A unit multiparticulate dosage form for delivering one or more basic, activepharmaceutical ingredients into the body in need of such medications toachieve target PK (pharmacokinetics) profiles is described. The dosage formcomprises one or more multicoated drug particles (beads, pellets, mini-/micro-tablets) having a barrier coating and a lag-time coating. Each Timed PulsatileRelease (TPR) bead population exhibits predetermined lag-time followed bydiffering release characteristics. The composition and thickness of thebarrier coating, composition and thickness of the lag-time coating, ratio ofIR beads to one or more TPR bead populations and total dose may be varieddepending on the alkalinity, pH-dependent solubility and elimination half-lifeof the active ingredients to achieve target PK profiles (suitable for a onceor twice daily dosing regimen) in patients in need of such medications.
