Compositions and methods thereof, for preventing or minimizing skin penetration and that promote surface-layer fixation of dermatological molecules in a human body are disclosed. The molecules of the present invention and compositions containing said molecules comprise a tissue-reactive part, an amphiphilic part, a light-functional part and optionally a detachment mechanism for releasing said tissue-reactive part from said light-functional part. The methods include ways of combining the tissue-reactive part, amphiphilic part, light-functional part and optionally synthesizing a detachment mechanism therein. The parts when combined form molecular structures possessing novel photobiological persistence and efficacy.
