Pyrazine derivatives as enac blockers

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专利权人:

NOVARTIS AG

发明人:

BHALAY GURDIP,EDWARDS LEE,HOWSHAM CATHERINE,HUNT PETER,SMITH NICHOLA

申请号：

NZ60837611

公开号：

NZ608376A

申请日:

2011.09.16

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Provided are pyrazine derivative compounds,of Formula (I), wherein the variables are as described in the specification. Examples of the compounds include 3-(3-{ 2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1 ,3,8-triazaspiro[4.5]decane-8-carbonyl} -benzenesulfonylamino)-propionic acid dipropylcarbamoylmethyl ester and 1-[(3-{ 2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimine ]-1,3,8-triazaspiro[4.5]decane-8-carbonyl} -benzenesulfonylamino)-methyl]-cyclobutanecarboxylic acid 2-oxo-2-(2-trifluoromethyl-pyrrolidin-1-yl)-ethyl ester. The compounds are blockers of the epithelial sodium channel (ENaC). The compounds are useful in the treatment of respiratory diseases.

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