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Pyrazine derivatives as enac blockers
专利权人:
NOVARTIS AG
发明人:
BHALAY GURDIP,EDWARDS LEE,HOWSHAM CATHERINE,HUNT PETER,SMITH NICHOLA
申请号:
NZ60837611
公开号:
NZ608376A
申请日:
2011.09.16
申请国别(地区):
NZ
年份:
2015
代理人:
摘要:
Provided are pyrazine derivative compounds,of Formula (I), wherein the variables are as described in the specification. Examples of the compounds include 3-(3-{ 2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1 ,3,8-triazaspiro[4.5]decane-8-carbonyl} -benzenesulfonylamino)-propionic acid dipropylcarbamoylmethyl ester and 1-[(3-{ 2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimine ]-1,3,8-triazaspiro[4.5]decane-8-carbonyl} -benzenesulfonylamino)-methyl]-cyclobutanecarboxylic acid 2-oxo-2-(2-trifluoromethyl-pyrrolidin-1-yl)-ethyl ester. The compounds are blockers of the epithelial sodium channel (ENaC). The compounds are useful in the treatment of respiratory diseases.
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中国工程科技知识中心
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