A Luer access device may include a housing, a septum, and a gas permeable vent in communication with at least a portion of the housing for venting gas from an extravascular system. A method of venting a medical device may include providing a gas permeable vent within a Luer access device as part of an extravascular system and venting gas from the extravascular system through the gas permeable vent of the Luer access device.