Binghe Wang,Yueqin ZHENG,Kaili JI,Bingchen YU,Zhixiang PAN
申请号：
US15563887
公开号：
US20180118674A1
申请日:
2016.04.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides methods of forming hydrogen sulfide. The methods include contacting a precursor compound with an unmasking agent； wherein the precursor compound comprises a hydrogen sulfide releasing moiety and a masked nucleophile； and wherein the contacting is conducted under conditions sufficient for cyclization of the precursor compound via lactone or lactam formation； thereby releasing hydrogen sulfide from the precursor compound. Hydrogen sulfide precursor compounds according to Formula I are also described, as well as methods for treating diseases and conditions using hydrogen sulfide precursors.
