Julia Castro Pichel,Raquel Fernandez Menendez,Esther Pilar Fernandez Velando,Silvia Gonzalez Del Valle,Araceli Mallo-Rubio
申请号：
US13878889
公开号：
US08779153B2
申请日:
2011.10.11
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A compound of Formula (I) or a pharmaceutically acceptable salt thereof:Wherein: Het is a 5 to 10-membered heteroaromatic ring Either X is N and Y is CR5 or X is C and Y is S Z is selected from N and CH R1 is selected from H and C1-2alkyl R2 is selected from H, C1-2alkyl, OH, —CH2OH and C1-2alkoxy Each R3 is independently selected from OH, C1-3alkyl, F, Cl, Br, NH2, and C1-3alkoxy R4 is selected from C1-3alkyl and haloC1-3alkyl R5 is selected from H, C1-3alkyl and haloC1-3alkyl R6 and R7 are either i) each independently selected from H, C1-3alkyl and C1-3alkoxy or ii) R6 and R7 together with the ring to which they are attached form a 9-membered bicylic ring p is 0-3 and RA is selected from H and C1-3alkyl, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.
