Peter Carmeliet,Frederik De Smet,Joost Schymkowitz,Frédéric Rousseau,Corentin Herbert
申请号：
US14954301
公开号：
US20160193192A1
申请日:
2015.11.30
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to an extracellular binding domain for an allosteric inhibitor, whereby said binding domain is derived from a single membrane span tyrosine kinase receptor. More specifically, the invention relates to an extracellular domain derived from a Fibroblast Growth Factor Receptor (FGFR). It further relates to the use of this domain for the identification of similar domains in the extracellular part of other tyrosine kinase receptors, and to a screening method for identification of a small compound allosteric inhibitor.
