PURPOSE: An anti-inflammatory composition containing Ficus erecta var. sieboldii leaf extract is provie to treat arthritis and to manufacture functional drink and drug. CONSTITUTION: An anti-inflammatory composition containing: Ficus erecta var. sieboldii leaf extract isolated using alcohol of C1-C5, acetone, hexane, ethyl acetatae, dichloromethane, water, or mixture solvent thereof； Ficus erecta var. sieboldii leaf extract obtained by fractioning Ficus erecta var. sieboldii leaf solid extract with mixture solvent of water and hexane, water and dichloromethane, or water and ethyl acetate； and Ficus erecta var. sieboldii leaf extract obtained by suspending solid extract in the water and fractioning with hexane, dichloromethane, ethyl acetate in order.본 발명은 NO(Nitric Oxide) 생성 억제 활성, PGE2와 염증성 사이토카인인 TNF-α, IL-6 및 IL-1β의 생성 억제 활성, iNOS 및 COX-2의 발현 억제 활성을 가지는 좁은잎천선과 잎 추출물을 이용한 항염증제 조성물을 개시한다.
