Fred D. Finkelman,Marat V. Khodoun,Durga Krishnamurthy,Richard T. Strait,Zeynep (Yesim) Kucuk
申请号：
US14111208
公开号：
US20140314783A1
申请日:
2012.04.12
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Provided are methods for suppressing IgE and IgG-mediated allergic reactions through monoclonal antibody applications. More specifically, methods are herein provided for safe induction of rapid desensitization. Specific embodiments are herein provided for suppressing allergic reactions in a subject, including specific methods of providing a monoclonal antibody selected from the group consisting of anti-FcαRIa and anti-FcγRIIb/RIII administering the antibody to a subject at a dose that is lower than the level required to induce shock and administering sequentially escalating doses of the monoclonal antibody so as to induce rapid desensitization to an allergen, thereby suppressing allergic reaction in the subject.
