Jae Myoung Suh,Michael Downes,Ronald M. Evans,Annette Atkins
申请号：
US15092097
公开号：
US20160237133A1
申请日:
2016.04.06
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure provides chimeric proteins having an N-terminus coupled to a C-terminus, wherein the N-terminus comprises an N-terminal portion of fibroblast growth factor (FGF) 2 and the C-terminus comprises a portion of an FGF1 protein. Such FGF2/FGF1 chimeras can further include a fibroblast growth factor receptor (FGFR) 1c-binding protein, a β-Klotho-binding protein, or both. Also provided are nucleic acid molecules that encode such proteins, and vectors and cells that include such nucleic acids. Methods of using the disclosed molecules to reduce blood glucose levels are also provided.
