A method includes determining a registration transform between first three dimensional pre-scan image data and second three dimensional pre-scan image data based on a predetermined registration algorithm. The method further includes registering first volumetric scan image data and second volumetric scan image data based on the registration transform. The method further includes generating registered image data. A system (100) includes a pre-scan registerer (122) that determines a registration transform between first three dimensional pre-scan image data and second three dimensional pre-scan image data based on a predetermined registration algorithm. The system further includes a volume registerer (126) that registers first volumetric scan image data and second volumetric scan image data based on the registration transform, generating registered image data.
