INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
发明人:
CHUN, Changju,전창주,CAI, Bangrong,채방영
申请号：
KRKR2017/002368
公开号：
WO2017/191893A1
申请日:
2017.03.06
申请国别(地区):
WO
年份:
2017
代理人:
摘要：
The present invention relates to a conjugate in which a primary amine is coupled to diosgenin via a linker, a preparation method therefor, and an anticancer composition comprising the same. With the introduction of a linear hydrophilic primary amine into the 3-OH position of diosgenin, the conjugate has the effect of exhibiting improved penetrability into a cancer cell membrane and thus significantly increasing in anticancer activity compared to diosgenin itself.La présente invention concerne un conjugué dans lequel une amine primaire est couplée à la diosgénine par lintermédiaire dun lieur, un procédé de préparation de ce dernier, et une composition anticancéreuse comprenant ce dernier. Avec lintroduction dune amine primaire linéaire hydrophile en position 3-OH de la diosgénine, le conjugué induit la manifestation dune amélioration de la capacité à pénétrer la membrane des cellules cancéreuses et, par conséquent, dune augmentation significative de lactivité anticancéreuse par rapport à la diosgénine elle-même.본 발명은 1차 아민 및 디오스제닌이 링커로 결합된 컨쥬게이트, 이의 제조방법 및 이를 포함하는 항암용 조성물에 관한 것으로, 디오스제닌의 3-OH 위치에 친수성 선형의 1차 아민을 도입함에 따라서, 암세포막 투과도가 향상되어 항암활성이 디오스제닌 자체에 비해 현저히 향상되는 효과가 있다.
