The General Hospital Corporation D/B/A Massachusetts General Hospital;Ethicon Endo-Surgery, Inc.
发明人:
Lee M. Kaplan,Nicholas Stylopoulos,Jason L. Harris,Dwight Henninger,Taylor W. Aronhalt,James W. Voegele
申请号：
US15175777
公开号：
US20170000827A1
申请日:
2016.06.07
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.
