In one embodiment, provided herein are cells, e. g., T cells expressing receptors that that cause a cell expressing the receptors to home to specific anatomical regions, e. g., the B cell zone of lymph nodes, the gastrointestinal tract, or the skin. Also provided herein is use of such cells, e.g., T lymphocytes, to treat diseases such as cancer.在一個實施例中,本文提供細胞(例如T細胞)表現受體,使得表現該等受體之細胞回歸至特定解剖區,例如淋巴結B細胞區、腸胃道或皮膚。本文亦提供此類細胞(例如T淋巴球)治療諸如癌症之疾病的用途。