The present invention provides monoclonal antibodies specific for one or more truncated variants of human osteopontin and vaccines comprising at least one isolated osteopontin peptide, as well methods for manufacturing said antibodies and vaccines. Furthermore, a diagnostic method making use of said antibodies is provided. Said antibodies and vaccines are used in therapy, especially in treatment and/or prevention of type-2 diabetes and cardiovascular disease.本發明提供針對一或多種人類骨調素的截斷變異體具有專一性的單株抗體及疫苗,包含至少一經分離之人類骨調素胜肽,以及製造所述抗體及疫苗的方法。此外,本發明另提供利用所述抗體的診斷方法。所述抗體及疫苗係用於治療方法之應用,特別是治療及/或預防第二型糖尿病及心血管疾病。
