GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
DEMARTINO, Michael P.,GUAN, Huiping Amy
申请号：
IBIB2017/050981
公开号：
WO2017/145050A1
申请日:
2017.02.21
申请国别(地区):
IB
年份:
2017
代理人:
摘要：
This invention relates to a novel compound which is an inhibitor of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing it, to processes for its preparation, and to its use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity. Formula (I)La présente invention concerne un nouveau composé qui est un inhibiteur de la kinase réarrangée au cours de la transfection (RET), des compositions pharmaceutiques le contenant, des procédés pour sa préparation, et son utilisation en thérapie, seul ou en combinaison, pour la normalisation de la sensibilité, motilité et/ou sécrétion gastro-intestinale, et/ou pour les maladies ou troubles abdominaux et/ou
