The invention relates to a single use syringe with a locking needle safety cover. The single use syringe includes a piston arm, a piston end, a syringe body, a fixation sleeve, and the locking needle safety cover, in which the piston end is engaged to the piston arm by at least one protruded tip. A sleeve rib located on the fixation sleeve is locked on the syringe body when a user pulls the piston arm back, to limit the fixation sleeve not to be forwardly moved again. If the user performs a push-press action on the piston arm, the protruded tip is disengaged from the fixation sleeve to separate the piston arm from the piston end. After that, the piston arm and the piston end cannot be engaged with each other again. Besides, when the user rotates the locking needle safety cover, an injection needle of the syringe is engaged in the locking needle safety cover. Accordingly, the purpose of unable to repeatedly use the single use syringe with the locking needle safety cover can be attained.一種具有閉鎖針頭安全蓋之一次性注射器,包含有一活塞臂、一活塞端、一注射器本體、一固定套筒、以及一閉鎖針頭安全蓋。活塞端係利用至少一突出尖端而卡合於活塞臂。當使用者回拉活塞臂時,固定套筒上的套筒凸肋將卡掣於注射器本體,以限制固定套筒再次被往前推動。若使用者推壓活塞臂,則突出尖端將脫離固定套筒,使得活塞臂與活塞端分離,之後,二者將無法再次卡合。除此之外,當使用者旋轉閉鎖針頭安全蓋,將使得注射器之注射針頭卡合進安全蓋中,藉此,此種具有閉鎖針頭安全蓋之一次性注射器達到無法被重複使用之目的。10...具有閉鎖針頭安全蓋之一次性注射器120...連接柄200...固定套筒410...本體壁430...注射針頭500...閉鎖針頭安全蓋510...安全蓋本體