A diazepinedione derivative represented by the formula(I) or a pharmacologically acceptable salt thereofis used as a P2X4 receptor antagonist:(See Formula I)wherein R1 represents a hydrogen atom, an alkyl grouphaving 1 to 8 carbon atoms, or the like, R2 and R3 representa hydrogen atom, an alkyl group having 1 to 8 carbonatoms, a halogen atom, or the like, R4 and R5 represent ahydrogen atom, an alkyl group having 1 to 8 carbon atoms,or the like, and W represents tetrazole or the like.
