The Trustees of the Stevens Institute of Technology
发明人:
Carrie E. Perlman
申请号：
US13650759
公开号：
US09504796B2
申请日:
2012.10.12
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Methods are provided for protecting against ventilation-induced lung injury both directly, by lowering surface tension, and indirectly, by promoting equitable liquid distribution in pulmonary alveolar edema, in which liquid- and air-filled alveoli are normally interspersed. Since a pressure barrier is responsible for trapping liquid in discrete edematous alveoli and the magnitude of the barrier is proportional to surface tension at the air-liquid interface, the present invention provides various methods for promoting equitable redistribution of edema liquid amongst alveoli to help protect the lung during ventilation, including: i) use of an additive that lowers surface tension； ii) use of active, accelerated deflation during mechanical ventilation； and iii) high frequency (>；50 Hz) vibration of the lung.
