#$%^&*AU2012200101A120120202.pdf#####C:NRPOrtbl DCC AM 407%75 I DOC-/01/2012 ABSTRACT The present invention relates to the discovery of a transdermal delivery system that can deliver low and high molecular weight compounds, particularly pharmaceuticals and cosmetic agents to a subject. A novel transdermal delivery system with therapeutic and cosmetic application and methods of use of the foregoing is disclosed.