Urszula GRABOWSKA,Lourdes SALVADORE-ODEN,Victor M. DIAZ PEREZ,Andrew CARR
申请号：
MX2016001978
公开号：
MX2016001978A
申请日:
2014.08.13
申请国别(地区):
MX
年份:
2017
代理人:
摘要：
There is provided Form 2 crystalline polymorph consisting of N-[1-6-(ethynyl-3-oxo-hexahydro-furo[3,2-b]pyrrole-4-carbonyl)- 3-methyl-butyl]-4-[5-fluoro-2-(4-methyl-piperazin-1-yl)thiazol-4 -yl]-benzamide monohydrochloride and N-[1-6-(ethynyl-3-oxo-hexahydro-furo[3,2-b]pyrrole-4- carbonyl)-3-methyl-butyl]-4-[5-fluoro-2-(4-methyl-piperazin-1-y l)thiazol-4-yl]-benzamide hydrate monohydrochloride, its use as a medicament and methods for its preparation.Se proporciona una forma 2 cristalina polimorfa que consiste de monoclorhidrato de N-[1-6-(etinil-3-oxo-hexahidro-furo[3,2-b]pirro lo-4-carbonil)-3-metil-butil]-4-[5-fluoro-2-(4-metil-piperazin-1- iI)tiazol-4-iI]-enzamida y monoclorhidrato hidrato de N-[1-6-(etinil-3-oxo-hexahidro-furo[3,2-b]pirrolo-4-carbonil)-3-m etil-butil]-4-[5-fluoro-2-(4-metil-piperazin-1-iI)tiazol-4-iI]-be nzamida, su uso como un medicamento y métodos para su preparación.
