The invention belongs to the field of medicinal chemistry and discloses a novel phosphoinositide 3-kinase inhibitor and a preparation method and application thereof. The structure of the phosphoinositide 3-kinase (PI3K) inhibitor in the present invention is shown in Formula I, and has various pharmacological activities such as anti-tumor, anti-neurodegenerative disease, and anti-inflammatory.本發明屬於藥物化學領域，公開了一種新穎磷酸肌醇3-激酶抑制劑及其製備方法和用途。本發明中的磷酸肌醇3-激酶(PI3K)抑制劑的結構如式I所示，具有抗腫瘤、抗神經退行性疾病、抗發炎等多種藥理活性。
