LAU, JOHNSON YIU-NAM,VERONE-BOYLE, ALISSA RAE,WONG, CHUN-HO,BU, YAHAO,CUTLER, MURRAY JOHN,BELKO, KRISTA ELIZABETH,KWAN, MIN-FUN RUDOLF
申请号:
CA3092939
公开号:
CA3092939A1
申请日:
2019.03.06
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
Compositions and methods are provided that are effective in treating skin hyperproliferative disorders. These include a topical pharmaceutical preparation that includes a compound that has two or more of a SRC-kinase inhibiting activity, a tubulin polymerization inhibiting activity, an activity that arrests the cell cycle at G2/M, and an activity that induces apoptosis. The compound KX01 is provided as an example of such a compound. The topical pharmaceutical preparation further includes a vitamin D derivative or a retinoid, where the combination provides a synergistic effect. Use of the topical pharmaceutical preparation can be combined with exposure to blue, UVA, or UVB light, which provides a synergistic effect.