An ultrasound ablation system can include an imaging device (50) for capturing first imaging of a region of interest, a processor (75) for receiving a selection of a planned target volume using the first imaging, and an ultrasound transducer (170) for performing first ultrasound ablation on the planned target volume. The processor can select ultrasound ablation shapes from a library of ultrasound ablation shapes. The ultrasound transducer can apply energy to the planned target volume based at least in part on the selected ultrasound ablation shapes. The imaging device can capture second imaging of the region of interest after application of the first ultrasound ablation. The processor can select other ultrasound ablation shapes from the library of ultrasound ablation shapes based at least in part on the second imaging.