Carole Yvone Louise Ghislaine Charlier,Mathew Douglas Littlejohn,Richard John Spelman,Michel Alphonse Jumien Georges
申请号：
NZ71923613
公开号：
NZ719236A
申请日:
2013.12.18
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Disclosed is a method for determining whether or not a non-human animal, non-human animal cell or non-human embryo carries a genetic marker linked to offspring mortality, the method comprising at least the step of analysing a nucleic acid from said non-human animal to determine whether or not it includes the genetic marker 24720155TTdel at a position corresponding to position 24720155 on chromosome 26 of Bos taurus and/or one or more genetic marker in linkage disequilibrium therewith, wherein where the nucleic acid includes said genetic marker and/or one or more genetic marker in linkage disequilibrium therewith, the non-human animal is determined to carry a genetic marker linked to offspring mortality. Also disclosed is a method for determining whether or not a non-human animal, non-human animal cell or non-human embryo carries a biological marker linked to offspring mortality, the method comprising at least the step of analysing the amino acid sequence of one or more OBFC1, one or more precursor thereof, one or more isoform thereof and/or one or more fragment thereof from said non-human animal to determine whether or not it includes a variation in the amino acid sequence corresponding to a variation in OBFC1 comprising a truncation from the amino acid at position 154 of OBFC1, wherein where it includes said variation in the amino acid sequence, the non-human animal is determined to carry a biological marker linked to offspring mortality.
