The present invention relates to a low irritant transdermal preparation for anti-inflammatory analgesic, and a preparing method thereof, and more particularly, to a low irritant transdermal preparation for anti-inflammatory analgesic, which has an excellent anti-inflammatory analgesic effect, and has an appropriate adhesion to a human skin, and a preparing method thereof. The preparing method of the transdermal preparation for anti-inflammatory analgesic, comprises the steps of: (a) uniformly mixing natural rubber, polyisobutylene and a tackifying resin at 85±5° C using a pressure kneader； (b) lowering a temperature of the pressure kneader down to 75±5° C, and uniformly mixing an absorbent polymer while adding the same； (c) lowering the temperature of the pressure kneader down to 65±5° C, and uniformly mixing an anti-inflammatory analgesic drug while adding the same to prepare a drug layer； (d) applying the prepared drug layer to a release layer； and (e) laminating the drug layer applied to the release layer with a support. The drug layer of the transdermal preparation for anti-inflammatory analgesic according to the present invention is prepared by mixing a rubber-based adhesive foundation having a specific composition, a tackifying resin, an absorbent polymer, and an anti-inflammatory analgesic drug at low temperatures of 60 to 90° C, and thus, the transdermal preparation for anti-inflammatory analgesic including the drug layer has excellent anti-inflammatory analgesic effect and skin adhesion but low skin irritation.본 발명은 저자극성 진통소염용 경피제제 및 이의 제조방법에 관한 것으로서, 더욱 상세하게는 진통 소염효과가 우수하고, 인체 피부에 적절한 점착력을 갖는 저자극성 진통소염용 경피제제 및 이의 제조방법에 관한 것이다. 상기 진통소염용 경피제제의 제조방법은 (a) 가압 니더기를 이용하여 85℃±5℃에서 천연고무, 폴리이소부틸렌 및 점착 부여 수지를 균일하게 혼합하는 단계； (b) 가압 니더기의 온도를 75℃±5℃로 낮추고, 흡수성 고분자를 첨가하면서 균일하게 혼합하는 단계； (c) 가압 니더기의 온도를 65℃±5℃로 낮추고, 진통소염제를 첨가하면서 균일하게 혼합하여 약물층을 제조하는 단계； (d) 제조된 약물층을 이형층에 도포하는 단계； 및 (e) 상기 이형층에 도포된 약물층을 지지체와 합지하는 단계를 포함한다.본 발명에 따른 진통소염용 경피제제의 약물층은 60~90℃의 낮은 온도에서 특정 조성의 고무
