GlaxoSmithKline Intellectual Property Development Limited
发明人:
Anne Marie Jeanne Bouillot,Alexis Denis,Ann Louise Walker,John Liddle
申请号：
US15537805
公开号：
US09932328B2
申请日:
2015.12.17
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Compound of formula (I)wherein:R1 is heteroaryl either unsubstituted or substituted by methyl, ethyl, halo or ═O； andR2 is H, methyl or ethyl；and salts thereof are KMO inhibitors and may be useful in the treatment of various disorders, for example acute pancreatitis, chronic kidney disease, acute kidney disease, acute kidney injury, other conditions associated with systemic inflammatory response syndrome (SIRS), Huntington's disease, Alzheimer's disease, spinocerebellar ataxias, Parkinson's disease, AIDS-dementia complex, HIV infection, amylotrophic lateral sclerosis (ALS), depression, schizophrenia, sepsis, cardiovascular shock, severe trauma, acute lung injury, acute respiratory distress syndrome, acute cholecystitis, severe burns, pneumonia, extensive surgical procedures, ischemic bowel, severe acute hepatic disease, severe acute hepatic encephalopathy or acute renal failure.
