APELIAN DAVID,KING THOMAS H.,GUO ZHIMIN,COESHOTT CLAIRE
申请号：
NZ70518412
公开号：
NZ705184A
申请日:
2012.02.09
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is an immunotherapeutic composition comprising: a) a yeast vehicle； and b) a fusion protein comprising HBV antigens, wherein the HBV antigens consist of: i) an HBV surface antigen having an amino acid sequence that is at least 90% identical to positions 1 to 399 of SEQ ID NO:118, positions 1 to 399 SEQ ID NO:116, positions 1 to 399 SEQ ID NO: 114 or positions 1 to 399 SEQ ID NO:112； and ii) an HBV core antigen having an amino acid sequence that is at least 90% identical to positions 400 to 581 of SEQ ID NO:118, positions 400 to 581 SEQ ID NO:116, positions 400 to 581 SEQ ID NO: 114 or positions 400 to 581 SEQ ID NO:112； wherein the composition elicits an HBV-specific immune response, wherein the fusion protein is expressed by the yeast vehicle, and wherein the sequences are as defined in the complete specification.
