PROBLEM TO BE SOLVED: To provide a skin external preparation that promotes the production of filaggrin, involucrin, loricrin, histidase, and SPRR1B, normalizes a skin function, inhibits wrinkle formation, prevents a rough skin, normalizes a skin texture, and is effective against atopic dermatitis and the like.SOLUTION: The problem is solved by extraction of a Citrus junos extract, preferably a Citrus junos fruit with an alcohol aqueous solution and lyophilization of it.EFFECT: The external preparation has the effects of inhibiting wrinkle formation, preventing a rough skin, normalizing a skin texture, and promoting skin cornification.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2018,JPO&INPIT【課題】フィラグリン、インボルクリン、ロリクリン、ヒスチダーゼ、SPRR1Bの産生を促進し、皮膚機能を正常化、シワ形成を抑制、肌荒れを防止、肌理正常化し、アトピー性皮膚炎等に有効な皮膚外用剤の提供。【解決手段】ユズの抽出物、好ましくはユズ果実をアルコール水溶液で抽出し、凍結乾燥することによる。【効果】前記外用剤は、シワ形成抑制、肌荒れ防止、肌理正常化、皮膚角化促進に効果がある。【選択図】図1
