תצמיד פוליפפטיד המכיל פולפפטיד פקטור vii המכיל אתר גליקוליזה בחומצה אמינית 106 וסוכר קשור קוואלנטית, רצף נוקלאוטיד המקודד אותו, תא מארח המכיל רצף הנוקלאוטיד, השיטה ליצורו והשימוש בו
The present application relates to factor VII (FVII) or Factor VIIa (FVIIa) polypeptide conjugates, to their preparation and use in therapy, in particular for the treatment of a variety of coagulation-related disorders. These polypeptide conjugates comprise at least one non-polypeptide moiety covalently attached to a polypeptide, wherein the amino acid sequence of the polypeptide differs from that of wild-type FVII or FVIIa in that at least one amino acid residue comprising an attachment group for said non-polypeptide moiety has been introduced or removed. The conjugates of the present application have one or more improved properties as compared to commercially available rFVIIa, including increased functional in vivo half-life and/or increased plasma half-life, and/or increased bioavailability and/or reduced sensitivity to proteolytic degradation.
